تأثیر ترکیبی تمرین اختیاری و مصرف عصاره آلیوم پارادوکسوم بر سطوح آمیلوئید بتا (Aβ1-42) پلاسمای موش‌های صحرایی دیابتی

 Background:Amyloid-beta (Aβ), is one of the risk factors of Alzheimer’s disease (AD) that increases in diabetes. The aim of this study was to investigate the effect of 6 weeks of voluntary wheel running with Allium paradoxum supplementation on plasma Amyloid beta1-42 in the diabetic rats induced with Alloxan. Methods: In this laboratory experimental study 28 male ratsweighing 185±1 gm were randomly assigned to 4 groups: control, training, Allium, and Allium-training. Diabetes was induced with injecting Alloxan (120 mg/kg dissolved in saline) peritoneally. The traininggroup participated in voluntary wheel running for 6 weeks.   Results:Sixweeks of voluntary wheel running significantly increased the plasma Aβ1-42 levels in training group compared with control group (P<0.001). Also Aβ1-42 levels increased in training-Allium group in comparison with control group (P=0.029) and Allium (P=0.025). Nevertheless, plasma Aβ1-42 levels was not different between training-Allium and training (P=0.210) and Allium (P=0.944) groups.  Conclusion:The plasma Aβ1-42 levels of diabetic subjects  was increased following 6 weeks of voluntary exercise combined with Allium Paradoxum extract supplementation, but understanding the beneficial effects of this increase in plasma Aβ1-42 levels requires more studies.